Efficient "one-pot" synthesis of novel 3-azabicyclic spiro-1',2',4'-triazolidin-3'-thiones catalyzed by potassium superoxide and their in vitro antibacterial and antifungal activities.

A new series of novel 3-azabicyclic spiro 1',2',4'-triazolidin-3'-thiones 15-21 catalyzed by potassium superoxide under microwave irradiation have been synthesized and studied for their in vitro microbiological evaluation on clinically isolated bacterial strains namely Micrococcus luteus, Bacillus subtilis, Bacillus cereus, Pseudomonas aeuroginosa and fungal strains namely Aspergillus niger, Candida albicans, Candida 6 and Candida 51. Results of the in vitro microbiological evaluation of the synthesized compounds are discussed.