Ishikawa M, Nakata T, Shimizu T, Taniguchi N
Department of Obstetrics and Gynecology, Asahikawa Medical College.
Rinsho Byori. 1992 Apr;40(4):359-62.
A monoclonal antibody against manganese superoxide dismutase (Mn-SOD) was assessed for its use in detecting a marker for epithelial ovarian carcinoma. An enzyme-linked immunosorbent assay has been developed to detect serum Mn-SOD. With this assay, only 1.7% of the 240 healthy females tested had more than 130 ng per milliliter of serum Mn-SOD. In contrast, 39 of 66 patients (59.1%) with epithelial ovarian carcinoma showed high levels of Mn-SOD. The serum Mn-SOD increased according to the clinical stage and declined to reflect the effect of therapy. The determination of Mn-SOD levels proved to be a clinical useful marker for monitoring the response to treatment and to early detection of the recurrence of epithelial ovarian carcinomas.
评估了一种针对锰超氧化物歧化酶（Mn-SOD）的单克隆抗体在检测上皮性卵巢癌标志物方面的应用。已开发出一种酶联免疫吸附测定法来检测血清中的Mn-SOD。通过该测定法，在240名接受检测的健康女性中，只有1.7%的人血清Mn-SOD含量超过每毫升130纳克。相比之下，66例上皮性卵巢癌患者中有39例（59.1%）显示出高水平的Mn-SOD。血清Mn-SOD水平根据临床分期升高，并随着治疗效果而下降。Mn-SOD水平的测定被证明是监测上皮性卵巢癌治疗反应和早期复发检测的临床有用标志物。
