Ishikawa M, Yaginuma Y, Hayashi H, Shimizu T, Endo Y, Taniguchi N
Department of Obstetrics and Gynecology, Asahikawa Medical College, Japan.
Cancer Res. 1990 Apr 15;50(8):2538-42.
A monoclonal antibody against manganese superoxide dismutase was assessed for its use in detecting a marker for epithelial ovarian carcinoma. An enzyme-linked immunosorbent assay indicated that less than 1% of normal individuals had serum levels over 150 ng per ml of serum, whereas over 50% of such patients showed elevated amounts. The serum levels of manganese superoxide dismutase correlated with the clinical stage of the disease and with the effects of therapy. The antibody used reacts with cryopreserved epithelial ovarian carcinomas but not with normal adult ovary or other normal tissues. Determination of the levels of this enzyme should provide a useful method for detection and monitoring of responses to treatment of epithelial ovarian carcinomas.
对一种抗锰超氧化物歧化酶的单克隆抗体进行了评估，以确定其用于检测上皮性卵巢癌标志物的用途。酶联免疫吸附测定表明，正常个体中血清水平超过每毫升血清150纳克的不到1%，而超过50%的此类患者血清水平升高。锰超氧化物歧化酶的血清水平与疾病的临床分期及治疗效果相关。所使用的抗体与冷冻保存的上皮性卵巢癌发生反应，但不与正常成年卵巢或其他正常组织发生反应。测定这种酶的水平应为上皮性卵巢癌的检测及治疗反应监测提供一种有用的方法。
