Yahara O, Hashimoto K, Taniguchi N, Ishikawa M, Sato Y, Yamashita H, Ohno H
Department of Internal Medicine, Asahikawa Medical College, Japan.
Res Commun Chem Pathol Pharmacol. 1991 Jun;72(3):315-26.
Manganese-superoxide dismutase (Mn-SOD) concentration was measured in sera from 37 healthy controls and 101 patients with 11 forms of neuromuscular diseases including Duchenne muscular dystrophy (DMD) and polymyositis (PMS) by an enzyme-linked immunosorbent assay with the use of a monoclonal antibody against human liver Mn-SOD. Serum from patients with DMD had a significantly (P less than 0.05) lower concentration of Mn-SOD than control serum. On the other hand, the concentration of Mn-SOD was markedly higher in the serum of patients with untreated form of acute PMS. The enzyme appeared to provide a good index for monitoring of responses to treatment of acute PMS. Of other neuromuscular diseases Mn-SOD concentration decreased significantly (P less than 0.05) in Charcot-Marie-Tooth disease and Kennedy-Alter-Sung syndrome but increased significantly (P less than 0.05) in human T-cell lymphotrophic viruses-I-associated myelopathy. This enzyme profile seems to be specific to each neuromuscular disease.
通过使用抗人肝锰超氧化物歧化酶（Mn-SOD）的单克隆抗体的酶联免疫吸附测定法，对37名健康对照者以及101名患有包括杜氏肌营养不良症（DMD）和多发性肌炎（PMS）在内的11种神经肌肉疾病的患者的血清中的Mn-SOD浓度进行了测量。DMD患者的血清中Mn-SOD浓度显著低于对照血清（P<0.05）。另一方面，未经治疗的急性PMS患者血清中Mn-SOD浓度明显更高。该酶似乎为监测急性PMS的治疗反应提供了一个良好的指标。在其他神经肌肉疾病中，Charcot-Marie-Tooth病和肯尼迪-奥尔特-宋综合征患者的Mn-SOD浓度显著降低（P<0.05），而人类T细胞嗜淋巴病毒I型相关脊髓病患者的Mn-SOD浓度则显著升高（P<0.05）。这种酶谱似乎对每种神经肌肉疾病都具有特异性。
