Patrick C C, Virella G, McManus J F, Faulk W P, Hughson H D, Fudenberg H H
Lab Invest. 1979 May;40(5):603-14.
Histologic and immunofluorescence studies were performed in nine rabbits after daily administration of human serum albumin at a fixed dosage for periods up to 26 weeks. All but one of the rabbits studied by immunofluorescence showed IgG, C3, and fibrinogen deposits in the renal glomeruli and in the tubules or peritubular tissues. In most cases, human serum albumin could also be identified in the deposits. In two rabbits killed at week 10, kidney pathology was minimal; in one of the rabbits killed in the early phases of the disease and in all rabbits killed after week 20, there were obvious pathologic changes affecting glomeruli, tubules, and/or interstitium. Tubulointerstitial changes were absent in only one of the rabbits killed at late stages of human serum albumin administration, in spite of evidence of tubular deposition of immune complexes. These observations suggest that tubulointerstitial damage is at least as frequent as glomerular damage during the induction of chronic serum sickness.
对9只兔子每日给予固定剂量的人血清白蛋白，持续给药长达26周，之后进行了组织学和免疫荧光研究。通过免疫荧光研究的兔子中，除一只外，其余兔子的肾小球、肾小管或肾小管周围组织均显示有IgG、C3和纤维蛋白原沉积。在大多数情况下，沉积物中也能鉴定出人血清白蛋白。在第10周处死的2只兔子中，肾脏病理变化轻微；在疾病早期处死的1只兔子以及在第20周后处死的所有兔子中，均出现了影响肾小球、肾小管和/或间质的明显病理变化。尽管有免疫复合物在肾小管沉积的证据，但在人血清白蛋白给药后期处死的兔子中，只有1只没有出现肾小管间质变化。这些观察结果表明，在慢性血清病的诱发过程中，肾小管间质损伤至少与肾小球损伤一样常见。
