Wiermer Marcel, Feys Bart J, Parker Jane E
Max Planck Institute for Plant Breeding Research, Department of Plant-Microbe Interactions, Carl-von-Linné-Weg 10, D-50829 Cologne, Germany.
Curr Opin Plant Biol. 2005 Aug;8(4):383-9. doi: 10.1016/j.pbi.2005.05.010.
ENHANCED DISEASE SUSCEPTIBILITY 1 (EDS1) and its interacting partner, PHYTOALEXIN DEFICIENT 4 (PAD4), constitute a regulatory hub that is essential for basal resistance to invasive biotrophic and hemi-biotrophic pathogens. EDS1 and PAD4 are also recruited by Toll-Interleukin-1 receptor (TIR)-type nucleotide binding-leucine rich repeat (NB-LRR) proteins to signal isolate-specific pathogen recognition. Recent work points to a fundamental role of EDS1 and PAD4 in transducing redox signals in response to certain biotic and abiotic stresses. These intracellular proteins are important activators of salicylic acid (SA) signaling and also mediate antagonism between the jasmonic acid (JA) and ethylene (ET) defense response pathways. EDS1 forms several molecularly and spatially distinct complexes with PAD4 and a newly discovered in vivo signaling partner, SENESCENCE ASSOCIATED GENE 101 (SAG101). Together, EDS1, PAD4 and SAG101 provide a major barrier to infection by both host-adapted and non-host pathogens.
增强型疾病易感性1（EDS1）及其相互作用伴侣植物抗毒素缺陷4（PAD4）构成了一个调控枢纽，这对于对侵入性活体营养型和半活体营养型病原体的基础抗性至关重要。EDS1和PAD4还被Toll样白细胞介素-1受体（TIR）型核苷酸结合富含亮氨酸重复序列（NB-LRR）蛋白招募，以信号传导分离物特异性病原体识别。最近的研究表明，EDS1和PAD4在响应某些生物和非生物胁迫时转导氧化还原信号方面具有重要作用。这些细胞内蛋白是水杨酸（SA）信号传导的重要激活剂，并且还介导茉莉酸（JA）和乙烯（ET）防御反应途径之间的拮抗作用。EDS1与PAD4以及新发现的体内信号传导伴侣衰老相关基因101（SAG101）形成了几种分子和空间上不同的复合物。EDS1、PAD4和SAG101共同为宿主适应性和非宿主病原体的感染提供了主要屏障。
