Bolten W W
Ann Rheum Dis. 2006 Jan;65(1):7-13. doi: 10.1136/ard.2005.036269. Epub 2005 Jun 7.
Treatment of pain in rheumatoid arthritis must take into account the gastrointestinal and cardiovascular risk of individual patients. Adequate results are not yet available, and until they are, treatment recommendations must take into account, not only the more favourable gastrointestinal risk profile of selective COX-2 inhibitors, but also the potential atherothrombotic risk of any NSAID or selective COX-2 inhibitor treatment.
类风湿关节炎疼痛的治疗必须考虑个体患者的胃肠道和心血管风险。目前尚无足够的结果,在此之前,治疗建议不仅要考虑选择性COX-2抑制剂更有利的胃肠道风险特征,还要考虑任何非甾体抗炎药或选择性COX-2抑制剂治疗潜在的动脉粥样硬化血栓形成风险。