Pabst Oliver, Peters Thorsten, Czeloth Niklas, Bernhardt Günter, Scharffetter-Kochanek Karin, Förster Reinhold
Institute of Immunology, Hannover Medical School, Hannover, Germany.
J Immunol. 2005 Jun 15;174(12):7492-5. doi: 10.4049/jimmunol.174.12.7492.
During humoral immune responses, naive B cells differentiate into Ab-secreting plasma cells within secondary lymphoid organs. Differentiating plasma cells egress from their sites of generation and redistribute to other tissues, predominantly the bone marrow and mucosal tissues. In this study, we demonstrate that within peripheral lymph nodes newly generated plasma cells localize to medullary cords which express the beta(2) integrin ligand ICAM-1. In beta(2) integrin-deficient mice plasma cells accumulate inside the lymph nodes, resulting in severely reduced plasma cell numbers in the bone marrow. Since plasma cells isolated from beta(2) integrin-deficient animals migrate efficiently into the bone marrow when transferred i.v., our findings provide profound evidence that beta(2) integrins are required for the egress of plasma cells from peripheral lymph nodes.
在体液免疫应答过程中，初始B细胞在二级淋巴器官内分化为分泌抗体的浆细胞。分化中的浆细胞从其产生部位逸出并重新分布到其他组织，主要是骨髓和黏膜组织。在本研究中，我们证明在外周淋巴结中，新产生的浆细胞定位于表达β2整合素配体ICAM-1的髓索。在β2整合素缺陷小鼠中，浆细胞在淋巴结内积聚，导致骨髓中浆细胞数量严重减少。由于从β2整合素缺陷动物分离的浆细胞经静脉注射转移时能有效迁移到骨髓中，我们的研究结果提供了有力证据，表明β2整合素是浆细胞从外周淋巴结逸出所必需的。
