感染分枝杆菌、李斯特菌和立克次氏体的豚鼠腹膜渗出细胞培养物的抗菌产物。
Antibacterial product of peritoneal exudate cell cultures from guinea pigs infected with mycobacteria, listeriae, and rickettsiae.
作者信息
Sharma S D, Middlebrook G
出版信息
Infect Immun. 1977 Mar;15(3):745-50. doi: 10.1128/iai.15.3.745-750.1977.
Abstract
In an in vitro model of cellular immunity, the antibacterial product of immunologically mediated mononuclear cell activation was studied from guinea pigs infected with listeriae and rickettsiae and compared with the product previously described from animals infected with mycobacteria. We found that this product, active against gram-positive bacilli, appeared to be identical in the three different infections with regard to its heat stability, its chromatographic adsorption and elution pattern, its susceptibility to inactivation by proteolytic enzymes, and its antibacterial spectrum
摘要
在细胞免疫的体外模型中，对感染李斯特菌和立克次体的豚鼠免疫介导的单核细胞激活产生的抗菌产物进行了研究，并与先前描述的感染分枝杆菌动物产生的产物进行了比较。我们发现，这种对革兰氏阳性杆菌有活性的产物，在三种不同感染中，其热稳定性、色谱吸附和洗脱模式、对蛋白水解酶失活的敏感性以及抗菌谱似乎是相同的。
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