Chamandy Nicholas, Wolfson Christina
Department of Mathematics and Statistics, McGill University, Montreal, Quebec, Canada.
Neuroepidemiology. 2005;25(2):75-84. doi: 10.1159/000086287. Epub 2005 Jun 8.
This paper examines the associations between clinical dementia and underlying cause of death (UCD) in a population-based sample of seniors who took part in the Canadian Study of Health and Aging (CSHA). Cause-of-death data were obtained via death certificates for 2,924 of 2,982 deceased subjects. Among the decedents were 823 clinically demented and 670 clinically non-demented participants. Using logistic regression we examined factors associated with a particular UCD in the overall group and also in the subgroup of demented seniors. Dementia was found to be associated with an increased risk of death from pneumonia. Both Alzheimer's disease and vascular dementia appear to decrease the risk of mortality from neoplasm. To our knowledge, this study is the first of its kind that combines a large, representative sample with thorough clinical assessment of cognitive status.
本文在参与加拿大健康与老龄化研究（CSHA）的老年人群体样本中，研究了临床痴呆与潜在死因（UCD）之间的关联。通过死亡证明获取了2982名已故受试者中2924人的死因数据。在这些死者中，有823名临床痴呆参与者和670名临床非痴呆参与者。我们使用逻辑回归分析了整个群体以及痴呆老年亚组中与特定潜在死因相关的因素。研究发现，痴呆与肺炎死亡风险增加有关。阿尔茨海默病和血管性痴呆似乎都能降低肿瘤导致的死亡风险。据我们所知，本研究是首个将大型代表性样本与对认知状态进行全面临床评估相结合的此类研究。
