活性氧介导远紫外线对大肠杆菌细胞的致死作用。
Reactive oxygen species mediate lethality induced by far-UV in Escherichia coli cells.
作者信息
Gomes A A, Silva-Júnior A C T, Oliveira E B, Asad L M B O, Reis N C S C, Felzenszwalb I, Kovary K, Asad N R
机构信息
Departamento de Biofísica e Biometria, Instituto de Biologia Roberto Alcantara Gomes, Universidade do Estado do Rio de Janeiro, 20551-030 Rio de Janeiro, RJ, Brazil.
出版信息
Redox Rep. 2005;10(2):91-5. doi: 10.1179/135100005X38833.
The involvement of reactive oxygen species (ROS) in the induction of DNA damage to Escherichia coli cells caused by UVC (254 nm) irradiation was studied. We verified the expression of the soxS gene induced by UVC (254 nm) and its inhibition by sodium azide, a singlet oxygen (1O2) scavenger. Additional results showed that a water-soluble carotenoid (norbixin) protects against the lethal effects of UVC. These results suggest that UVC radiation can also cause ROS-mediated lethality.
研究了活性氧（ROS）在UVC（254nm）照射诱导大肠杆菌细胞DNA损伤中的作用。我们验证了UVC（254nm）诱导的soxS基因的表达及其被单线态氧（1O2）清除剂叠氮化钠的抑制作用。其他结果表明，水溶性类胡萝卜素（降胭脂树素）可保护细胞免受UVC的致死作用。这些结果表明，UVC辐射也可导致ROS介导的致死性。
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