Hallberg Mathias, Kindlundh Anna M S, Nyberg Fred
Division of Biological Research on Drug Dependence, Department of Pharmaceutical Biosciences, Uppsala University, Biomedical Center, Box 591, 75124 Uppsala, Sweden.
Peptides. 2005 Jul;26(7):1228-34. doi: 10.1016/j.peptides.2005.02.005. Epub 2005 Feb 26.
Adult male Sprague-Dawley rats were treated with the anabolic androgenic steroid nandrolone decanoate (15 mg/kg day) or oil vehicle (sterile arachidis oleum) during 14 days. The effect on the densities of the neurokinin NK1 receptor in brain was examined with autoradiography. An overall tendency of attenuation of NK1 receptor density was observed after completed treatment with nandrolone decanoate. The density of the NK1 receptor was found to be significantly lower compared to control animals in the nucleus accumbens core (37% density reduction), in dentate gyrus (26%), in basolateral amygdaloid nucleus (23%), in ventromedial hypothalamic nucleus (36%), in dorsomedial hypothalamic nucleus (43%) and finally in the periaqueductal gray (PAG) (24%). In the cortex region, no structures exhibited any significant reduction of NK1 receptor density. This result provides additional support to the hypothesis that substance P and the NK1 receptor may be involved as important components that participate in mediating physiological responses including the adverse behaviors often associated with chronically administrated anabolic androgenic steroids in human.
成年雄性Sprague-Dawley大鼠在14天内接受了合成代谢雄激素癸酸诺龙（15毫克/千克/天）或油性载体（无菌花生油）治疗。采用放射自显影法检测其对脑中神经激肽NK1受体密度的影响。在用癸酸诺龙完成治疗后，观察到NK1受体密度有总体降低趋势。与对照动物相比，伏隔核核心区（密度降低37%）、齿状回（26%）、基底外侧杏仁核（23%）、腹内侧下丘脑核（36%）、背内侧下丘脑核（43%）以及导水管周围灰质（PAG）（24%）中的NK1受体密度显著降低。在皮质区域，没有结构显示NK1受体密度有任何显著降低。这一结果为以下假设提供了额外支持，即P物质和NK1受体可能作为重要成分参与介导生理反应，包括人类中常与长期使用合成代谢雄激素类固醇相关的不良行为。
