Magnusson K, Birgner C, Bergström L, Nyberg F, Hallberg M
Department of Pharmaceutical Biosciences, Division of Biological Research on Drug Dependence, Uppsala University, Uppsala, Sweden.
Neuropeptides. 2009 Apr;43(2):105-11. doi: 10.1016/j.npep.2008.12.005. Epub 2009 Feb 7.
The kappa opioid receptor ligand [(3)H]CI-977 was used to autoradiographically determine the density of kappa opioid receptors in the male rat brain following chronic treatment with the anabolic androgenic steroid nandrolone decanoate at two different doses. As compared to controls, significantly lower densities of the kappa opioid receptor were encountered after two weeks of high dose nandrolone decanoate (15 mg/kg) in the nucleus accumbens shell (16%), lateral hypothalamic area (36%), ventromedial hypothalamic nucleus (37%), dorsomedial hypothalamic nucleus (49%), central amygdaloid nucleus, capsular part (28%), lateral globus pallidus (35%) and in the stria terminalis (24%). Furthermore, an up-regulation of the receptor level was observed in the caudate putamen (18%) and in the dorsal endopiriform nucleus (23%). These alterations in the kappa opioid receptor expression are possibly attributed to a previously observed pronounced impact of nandrolone decanoate on the dynorphinergic system and could also include involvement of the dopaminergic reward system.
使用κ阿片受体配体[(3)H]CI-977通过放射自显影法测定在雄性大鼠脑中，经两种不同剂量的合成代谢雄激素类固醇癸酸诺龙长期治疗后κ阿片受体的密度。与对照组相比，在高剂量癸酸诺龙（15毫克/千克）治疗两周后，伏隔核壳（16%）、下丘脑外侧区（36%）、下丘脑腹内侧核（37%）、下丘脑背内侧核（49%）、杏仁中央核被膜部（28%）、外侧苍白球（35%）以及终纹床核（24%）中的κ阿片受体密度显著降低。此外，在尾状壳核（18%）和背侧梨状内嗅核（23%）中观察到受体水平上调。κ阿片受体表达的这些改变可能归因于先前观察到的癸酸诺龙对强啡肽能系统的显著影响，并且还可能涉及多巴胺能奖赏系统。
