Bates Jason H T, Lutchen Kenneth R
Vermont Lung Center, University of Vermont College of Medicine, HSRF 228, 149 Beaumont Avenue, Burlington, VT 05405, USA.
Respir Physiol Neurobiol. 2005 Aug 25;148(1-2):153-64. doi: 10.1016/j.resp.2005.04.021.
The mechanical properties of the lung periphery are vital to the overall function of the whole organ, and play a key role in the symptomatology of many lung diseases. We first review the experimental methodologies that have been used to investigate peripheral lung mechanics, including the retrograde catheter, the alveolar capsule, the alveolar capsule oscillator, and the forced oscillation technique. We then discuss the interpretation of the data provided by these techniques in terms of inverse mathematical models of the lung, including the constant-phase model. Finally, we describe efforts to construct anatomically accurate forward models of the lung based on data from imaging modalities such as computed tomography and magnetic resonance imaging. Together, these various approaches have provided a great deal of information about the relative importance of the lung periphery in mechanical function in animal models of lung disease and in human patients. An increasing body of evidence indicates that constriction in this part of the lung is a crucial determinant of the severity of asthma.
肺周边的力学特性对整个器官的整体功能至关重要，并在许多肺部疾病的症状表现中起关键作用。我们首先回顾用于研究肺周边力学的实验方法，包括逆行导管、肺泡囊、肺泡囊振荡器和强迫振荡技术。然后，我们根据肺的逆数学模型，包括恒相模型，讨论这些技术所提供数据的解释。最后，我们描述基于计算机断层扫描和磁共振成像等成像模态数据构建肺的解剖学精确正向模型的努力。这些不同的方法共同提供了大量关于肺周边在肺部疾病动物模型和人类患者机械功能中的相对重要性的信息。越来越多的证据表明，肺部这一部分的收缩是哮喘严重程度的关键决定因素。
