Bremen Institute for Prevention Research and Social Medicine, Bremen, Germany.
Cancer Causes Control. 2010 Oct;21(10):1625-34. doi: 10.1007/s10552-010-9591-9. Epub 2010 Jun 4.
Several studies suggest that hormonal mechanisms may be associated with the development of uveal melanoma. Therefore, the association between the risk of uveal melanoma and exposure to hormonal exposures was investigated in a case-control study from nine European countries.
Incident cases of uveal melanoma were frequency-matched to population and hospital controls by country, age, and sex. Female subjects were asked about their reproductive history, use of menopausal hormone replacement therapy and oral contraceptives. Among men, occupational handling of oils while working with transformers or capacitors which contain polychlorinated biphenyls (PCB) was solicited. Unconditional logistic regression analyses were calculated, adjusting for several potential confounders. Analyses were stratified by sex.
Two hundred and ninety-three cases (165 men, 128 women) and 3,198 control subjects (2,121 men, 1,077 women) were interviewed. Among women, no associations were observed with hormonal status variables, intake of hormonal therapy or intake of oral contraceptives. Men showed an increased risk with occupational exposure to transformer/capacitor oils (OR = 2.74; Bonferroni-corrected 99.3% CI 1.07-7.02). However, these results were based on few exposed subjects only.
The results of this study do not support the hypothesis of a hormonal influence in the carcinogenesis of uveal melanoma. Our finding of a potentially increased risk with PCB-containing oils requires further research.
几项研究表明，激素机制可能与葡萄膜黑色素瘤的发生有关。因此，在来自九个欧洲国家的病例对照研究中，研究了激素暴露与葡萄膜黑色素瘤风险之间的关联。
按照国家、年龄和性别，将葡萄膜黑色素瘤的发病病例与人群和医院对照进行频数匹配。女性被问及她们的生育史、使用绝经后激素替代疗法和口服避孕药的情况。对于男性，则询问了他们在工作中接触含有多氯联苯 (PCB) 的变压器或电容器油的职业情况。通过条件逻辑回归分析，调整了几个潜在的混杂因素。按性别分层进行分析。
共采访了 293 例病例（165 名男性，128 名女性）和 3198 名对照受试者（2121 名男性，1077 名女性）。在女性中，没有观察到激素状态变量、激素治疗或口服避孕药的摄入与葡萄膜黑色素瘤之间存在关联。男性接触变压器/电容器油的职业暴露与风险增加相关（OR=2.74；Bonferroni 校正 99.3%CI 1.07-7.02）。然而，这些结果仅基于少数暴露于这些油的对象。
本研究的结果不支持激素对葡萄膜黑色素瘤发生有影响的假说。我们发现含有 PCB 的油可能会增加风险，需要进一步研究。
