Fischer Christian P, Perstrup Lisbeth B, Berntsen Annika, Eskildsen Peter, Pedersen Bente K
Centre of Inflammation and Metabolism, The Department of Infectious Diseases and The Copenhagen Muscle Research Centre, Rigshospitalet and The Faculty of Health Sciences, University of Copenhagen, DK-2100 Copenhagen, Denmark.
Clin Immunol. 2005 Nov;117(2):152-60. doi: 10.1016/j.clim.2005.07.008. Epub 2005 Aug 19.
Elevated plasma IL-18 is present in several conditions sharing insulin-resistance as common trait, but the association with insulin-resistance per se is not established. Plasma/serum IL-6, IL-18, TNF-alpha, soluble TNF receptor II (sTNFR2), and C-reactive protein (CRP) were measured in 97 patients with type 2 diabetes (DM) and 84 non-diabetic controls (CON). The association with insulin-resistance-estimated using the homeostasis model assessment (HOMA-IR)-was analyzed using multivariate linear and logistic regression. Compared to CON, DM demonstrated higher plasma levels of IL-18 (P = 0.001), IL-6 (P < 0.001), sTNFR2 (P = 0.005), and CRP (P < 0.001), while TNF-alpha was lower (P = 0.017). Plasma IL-18 increased across HOMA-IR quartiles in both DM and CON, both with and without adjustment for confounders (all P < 0.05). In contrast, neither IL-6, TNF-alpha, sTNFR2, nor CRP was associated with HOMA-IR in CON when adjusting for confounders. Accordingly, 50% increase of IL-18 corresponded to a marked increase of HOMA-IR in both DM and CON (DM: 26%, P = 0.014; CON: 25%, P = 0.003) after adjustment for confounders. Our results show that plasma IL-18 was associated with HOMA-IR independent of obesity and type 2 diabetes.
血浆白细胞介素-18（IL-18）升高存在于几种以胰岛素抵抗为共同特征的疾病中，但与胰岛素抵抗本身的关联尚未确立。对97例2型糖尿病（DM）患者和84例非糖尿病对照者（CON）测定了血浆/血清白细胞介素-6（IL-6）、白细胞介素-18、肿瘤坏死因子-α（TNF-α）、可溶性肿瘤坏死因子受体II（sTNFR2）和C反应蛋白（CRP）。使用稳态模型评估（HOMA-IR）估计胰岛素抵抗，并通过多变量线性和逻辑回归分析其相关性。与CON相比，DM患者的血浆IL-18（P = 0.001）、IL-6（P < 0.001）、sTNFR2（P = 0.005）和CRP（P < 0.001）水平更高，而TNF-α水平更低（P = 0.017）。在DM和CON中，无论是否对混杂因素进行校正，血浆IL-18均随HOMA-IR四分位数增加（所有P < 0.05）。相比之下，在对CON校正混杂因素后，IL-6、TNF-α、sTNFR2和CRP均与HOMA-IR无关。因此，在校正混杂因素后，IL-18增加50%对应于DM和CON中HOMA-IR的显著增加（DM：26%，P = 0.014；CON：25%，P = 0.003）。我们的结果表明，血浆IL-18与HOMA-IR相关，独立于肥胖和2型糖尿病。
