[血清S100蛋白与星形细胞瘤患者放射性脑损伤]
[Serum S100 protein and radiation-induced brain injury in astrocytoma patients].
作者信息
Song Wei-shu, Guo Li-bing, Hong Zhi-yong, Li Jun-Jie, Wu Jun
机构信息
Department of Oncology, Second People's Hospital of Guangdong Province, Guangzhou 510317, China.
出版信息
Di Yi Jun Yi Da Xue Xue Bao. 2005 Jun;25(6):723-5.
OBJECTIVE
To study the value of serum S100 protein in the diagnosis of radiation-induced brain injury in astrocytoma patients.
METHODS
Serum S100 protein levels were detected by enzyme-linked immunosorbent assay in 86 astrocytoma patients in the course of radiotherapy.
RESULTS
The positivity rates of serum S100 protein before, in the middle of and after radiotherapy were 0, 9.3% (8/86) and 19.8% (17/86), respectively, showing significant differences (P<0.05) between these time points for measurement.
CONCLUSION
High levels of serum S100 protein are associated with radiation-induced brain injury in astrocytoma patients and may serve as the marker for early diagnosis of the injury.
目的
探讨血清S100蛋白在星形细胞瘤患者放射性脑损伤诊断中的价值。
方法
采用酶联免疫吸附测定法检测86例接受放射治疗的星形细胞瘤患者血清S100蛋白水平。
结果
放疗前、放疗中和放疗后血清S100蛋白阳性率分别为0、9.3%（8/86）和19.8%（17/86），各测量时间点之间差异有统计学意义（P<0.05）。
结论
血清S100蛋白水平升高与星形细胞瘤患者放射性脑损伤有关，可能作为该损伤早期诊断的标志物。
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