Romero Linda J, Garry Philip J, Schuyler Mark, Bennahum David A, Qualls Clifford, Ballinger Lori, Kelly Velma, Schmitt Cheryl, Skipper Betty, Ortiz Irene E, Rhyne Robert L
Department of Family Medicine, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, 87131, USA.
J Genet Couns. 2005 Apr;14(2):141-50. doi: 10.1007/s10897-005-4063-1.
The purpose of our study is to assess the emotional responses to disclosing APO E genotype to asymptomatic older adults at increased risk for Alzheimer disease (AD). This is a longitudinal cohort study of volunteer subjects who were aged 50 years or over, asymptomatic for (AD), had a family history of AD, passed a psychological assessment, and participated in pre- and post-test genetic counseling and three follow-up visits over 10 months. We analyzed responses by three emotional constructs: depressed, worried, and relieved. Three hundred and twenty-eight subjects were screened, 76 received their APO E genotype. When emotional responses occurred it was immediate, between baseline and the 1 month follow-up. Emotional reactions did not change significantly past 1 month. Our results suggest that for emotionally stable persons, disclosing results of their APO E genotype, high risk subjects did not report more depression or worry and low risk subjects felt relieved by knowing the results. Future studies should evaluate the risks of disclosure to family members involved in the diagnostic work-up of a relative and include subjects from a broader range of emotional stability and socioeconomic background.
我们研究的目的是评估向患阿尔茨海默病（AD）风险增加的无症状老年人披露APOE基因型时他们的情绪反应。这是一项针对志愿者受试者的纵向队列研究，这些受试者年龄在50岁及以上，无AD症状，有AD家族史，通过了心理评估，并在10个月内参加了测试前和测试后的遗传咨询以及三次随访。我们通过三种情绪结构分析反应：抑郁、担忧和宽慰。共筛查了328名受试者，76名受试者得知了他们的APOE基因型。情绪反应是即时的，发生在基线和1个月随访之间。1个月后情绪反应没有显著变化。我们的结果表明，对于情绪稳定的人，披露其APOE基因型结果时，高风险受试者没有报告更多的抑郁或担忧情况，而低风险受试者因得知结果而感到宽慰。未来的研究应评估向参与亲属诊断检查的家庭成员披露信息的风险，并纳入来自更广泛情绪稳定性和社会经济背景的受试者。
