Takano Haruhito, Morita Toshihiro, Iida Haruko, Asada Ken-ichi, Kato Masayoshi, Uno Kansei, Hirose Ken, Matsumoto Akihiro, Takenaka Katsu, Hirata Yasunobu, Eto Fumio, Nagai Ryozo, Sato Yoshiaki, Nakajima Toshiaki
Department of Cardiovascular Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
Eur J Appl Physiol. 2005 Sep;95(1):65-73. doi: 10.1007/s00421-005-1389-1. Epub 2005 Jun 15.
We investigated the hemodynamic and hormonal responses to a short-term low-intensity resistance exercise (STLIRE) with the reduction of muscle blood flow. Eleven untrained men performed bilateral leg extension exercise under the reduction of muscle blood flow of the proximal end of both legs pressure-applied by a specially designed belt (a banding pressure of 1.3 times higher than resting systolic blood pressure, 160-180 mmHg), named as Kaatsu. The intensity of STLIRE was 20% of one repetition maximum. The subjects performed 30 repetitions, and after a 20-seconds rest, they performed three sets again until exhaustion. The superficial femoral arterial blood flow and hemodynamic parameters were measured by using the ultrasound and impedance cardiography. Serum concentrations of growth hormone (GH), vascular endothelial growth factor (VEGF), noradrenaline (NE), insulin-like growth factor (IGF)-1, ghrelin, and lactate were also measured. Under the conditions with Kaatsu, the arterial flow was reduced to about 30% of the control. STLIRE with Kaatsu significantly increased GH (0.11+/-0.03 to 8.6+/-1.1 ng/ml, P < 0.01), IGF-1 (210+/-40 to 236+/-56 ng/ml, P < 0.01), and VEGF (41+/-13 to 103+/-38 pg/ml, P < 0.05). The increase in GH was related to neither NE nor lactate, but the increase in VEGF was related to that in lactate (r = 0.57, P < 0.05). Ghrelin did not change during the exercise. The maximal heart rate (HR) and blood pressure (BP) in STLIRE with Kaatsu were higher than that without Kaatsu. Stroke volume (SV) was lower due to the decrease of the venous return by Kaatsu, but, total peripheral resistance (TPR) did not change significantly. These results suggest that STLIRE with Kaatsu significantly stimulates the exercise-induced GH, IGF, and VEGF responses with the reduction of cardiac preload during exercise, which may become a unique method for rehabilitation in patients with cardiovascular diseases.
我们研究了短期低强度抗阻运动（STLIRE）对血液动力学和激素的反应以及肌肉血流量的减少情况。11名未经训练的男性在通过特制腰带对双腿近端施加压力以减少肌肉血流量的情况下（绑扎压力比静息收缩压高1.3倍，即160 - 180 mmHg）进行双侧腿部伸展运动，这种运动方式称为加压训练（Kaatsu）。STLIRE的强度为一次重复最大值的20%。受试者进行30次重复，休息20秒后，再进行三组直至力竭。使用超声和阻抗心动图测量股浅动脉血流量和血液动力学参数。还测量了血清生长激素（GH）、血管内皮生长因子（VEGF）、去甲肾上腺素（NE）、胰岛素样生长因子（IGF）-1、胃饥饿素和乳酸的浓度。在加压训练的条件下，动脉血流量减少至对照组的约30%。采用加压训练的STLIRE显著增加了GH（从0.11±0.03增至8.6±1.1 ng/ml，P < 0.01）、IGF-1（从210±40增至236±56 ng/ml，P < 0.01）和VEGF（从41±13增至103±38 pg/ml，P < 0.05）。GH升高与NE和乳酸均无关，但VEGF升高与乳酸升高有关（r = 0.57，P < 0.05）。运动期间胃饥饿素未发生变化。采用加压训练的STLIRE中的最大心率（HR）和血压（BP）高于未采用加压训练时。由于加压训练使静脉回流减少，每搏输出量（SV）较低，但总外周阻力（TPR）无显著变化。这些结果表明，采用加压训练的STLIRE在运动期间通过降低心脏前负荷显著刺激了运动诱导的GH、IGF和VEGF反应，这可能成为心血管疾病患者康复的一种独特方法。
