Cardellach F, Galofré J, Grau J M, Casademont J, Hoek J B, Rubin E, Urbano-Márquez A
Department of General Internal Medicine, Hospital Clínic i Provincial, University of Barcelona, Spain.
Ann Neurol. 1992 May;31(5):515-8. doi: 10.1002/ana.410310509.
We investigated the effect of long-term ethanol intake on the function of skeletal muscle mitochondria from 30 human alcoholics. Mitochondrial studies included (1) oxidative phosphorylation, (2) the activity of the individual complexes of the respiratory chain, and (3) the cytochrome content. State 3 and state 4 oxidation rates with glutamate-malate, succinate, tetramethyl-p-phenylenediamine-ascorbate, and acetylcarnitine-malate, the activity of the individual complexes of the respiratory chain, and the concentration of mitochondrial cytochromes were comparable in control subjects and alcoholic patients, and also in myopathic and nonmyopathic alcoholic patients. These results demonstrate that alcoholic myopathy is not associated with a deficiency in mitochondrial energy supply.
我们研究了长期摄入乙醇对30名人类酗酒者骨骼肌线粒体功能的影响。线粒体研究包括：（1）氧化磷酸化；（2）呼吸链各复合体的活性；（3）细胞色素含量。对照组受试者与酗酒患者之间，以及患有肌病的酗酒患者与未患肌病的酗酒患者之间，以谷氨酸-苹果酸、琥珀酸、四甲基对苯二胺-抗坏血酸和乙酰肉碱-苹果酸为底物时的状态3和状态4氧化速率、呼吸链各复合体的活性以及线粒体细胞色素浓度均具有可比性。这些结果表明，酒精性肌病与线粒体能量供应不足无关。
