Rainbow Jean, Cebelinski Elizabeth, Bartkus Joanne, Glennen Anita, Boxrud Dave, Lynfield Ruth
Minnesota Department of Health, Minneapolis, Minnesota 55414, USA.
Emerg Infect Dis. 2005 Jun;11(6):977-9. doi: 10.3201/eid1106.050143.
Rifampin-resistant meningococcal disease occurred in a child who had completed rifampin chemoprophylaxis for exposure to a sibling with meningococcemia. Susceptibility testing of 331 case isolates found only 1 other case of rifampin-resistant disease in Minnesota, USA, during 11 years of statewide surveillance. Point mutations in the RNA polymerase Beta subunit (rpoB) gene were found in isolates from each rifampin-resistant case-patient.
一名儿童在完成针对接触患脑膜炎球菌血症的同胞的利福平化学预防后,发生了耐利福平的脑膜炎球菌病。在全州11年的监测期间,对331株病例分离株进行药敏试验发现,在美国明尼苏达州仅另有1例耐利福平疾病。在每例耐利福平病例患者的分离株中均发现了RNA聚合酶β亚基(rpoB)基因的点突变。