Department of Pharmaceutical Sciences, University of Pittsburgh, School of Pharmacy, 3501 Terrace Street, 10064 Salk Hall, Pittsburgh, PA 15261, United States of America.
Department of Pharmaceutical Sciences, University of Pittsburgh, School of Pharmacy, 3501 Terrace Street, 10064 Salk Hall, Pittsburgh, PA 15261, United States of America.
Pharmacol Biochem Behav. 2023 Jun;227-228:173585. doi: 10.1016/j.pbb.2023.173585. Epub 2023 Jun 10.
Disinhibitory behavior during childhood and adolescence has been frequently shown to amplify the risk for substance use disorder (SUD) in adulthood. This prospective study examined the hypothesis that poor communication with parents and association with deviant peers comprise an SUD-promoting environtype which catalyzes transition of disinhibitory behavior toward SUD.
Male (N = 499) and female (N = 195) youths were tracked from 10 to 12 to 30 years of age. Path analysis evaluated the patterning of disinhibitory behavior and social environment during childhood on substance use during adolescence, and antisocial personality without co-occurring SUD in early adulthood and subsequently substance use disorder (SUD).
Disinhibitory behavior (SUD vulnerability) in childhood predicts antisociality without SUD (age 22) that segues to SUD (age 23-30) whereas the environtype (parents and peers) predicts substance use during adolescence which predicts antisocial personality leading to SUD. Antisociality without SUD in early adulthood mediates the association of substance use during adolescence and SUD.
Disinhibitory behavior and deviance-promoting social environment conjointly promote development of SUD via deviant socialization.
儿童和青少年时期的抑制解除行为经常被证明会增加成年后患物质使用障碍(SUD)的风险。本前瞻性研究检验了以下假设,即与父母沟通不良和与偏差同伴交往构成了促进 SUD 的环境类型,这种环境类型促使抑制解除行为向 SUD 转变。
从 10 岁到 12 岁到 30 岁,对男性(N=499)和女性(N=195)青少年进行跟踪。路径分析评估了儿童期抑制解除行为和社会环境模式对青少年期物质使用的影响,以及早期成年期无共病 SUD 的反社会人格和随后的物质使用障碍(SUD)。
儿童时期的抑制解除行为(SUD 易感性)预测成年期无 SUD 的反社会行为(22 岁),这会导致 SUD(23-30 岁),而环境类型(父母和同伴)预测青少年时期的物质使用,这预测反社会人格导致 SUD。早期成年期无 SUD 的反社会行为中介了青少年期物质使用和 SUD 之间的关联。
抑制解除行为和促进偏差的社会环境共同通过偏差社会化促进 SUD 的发展。