组氨酸-色氨酸-酮戊二酸溶液与威斯康星大学溶液作为接受搏动灌注的同种异体肾移植初始保存液的比较
Comparison of histidine-tryptophan ketoglutarate and University of Wisconsin solutions as primary preservation in renal allografts undergoing pulsatile perfusion.
作者信息
Agarwal A, Goggins W C, Pescovitz M D, Milgrom M L, Murdock P, Fridell J A
机构信息
Department of Surgery, Indiana University School of Medicine, 550 N. University Boulevard #4258, Indianapolis, IN 46202, USA.
出版信息
Transplant Proc. 2005 Jun;37(5):2016-9. doi: 10.1016/j.transproceed.2005.03.038.
INTRODUCTION
University of Wisconsin (UW) solution is the standard preservation solution for organ transplantation. Histidine-tryptophan ketogluatarate (HTK) solution has been used increasingly for kidney, pancreas, and liver transplantation. This study compared HTK and UW used during kidney procurement with subsequent pulsatile perfusion.
METHODS
Between January and October 2003, 91 deceased renal and simultaneous kidney pancreas transplants were performed (UW, n = 41, and HTK, n = 50). There were no differences with regard to donor and recipient demographics or cold ischemia.
RESULTS
Delayed graft function occurred in 3 (7%) of UW and 4 (8%) of HTK-preserved kidneys (P = NS). There were no significant differences between patient or graft survival. There was an anticipated difference between total preservative volumes used (HTK: 4.1 +/- 1.0 vs UW: 3.0 +/- 0.5; P < .005).
CONCLUSION
UW and HTK appear to have similar efficacy in kidney preservation with pulsatile perfusion. HTK preservation solution can be used safely in conjunction with pulsatile preservation for cold storage of renal allografts.
引言
威斯康星大学（UW）溶液是器官移植的标准保存溶液。组氨酸-色氨酸酮戊二酸（HTK）溶液已越来越多地用于肾脏、胰腺和肝脏移植。本研究比较了肾脏获取过程中使用HTK和UW溶液并随后进行搏动灌注的效果。
方法
2003年1月至10月期间，进行了91例尸体肾移植和同期肾胰联合移植（UW组41例，HTK组50例）。供体和受体的人口统计学特征或冷缺血时间方面无差异。
结果
UW溶液保存的肾脏中有3例（7%）发生移植肾功能延迟恢复，HTK溶液保存的肾脏中有4例（8%）发生移植肾功能延迟恢复（P=无统计学意义）。患者或移植物存活率无显著差异。所用总保存液体积存在预期差异（HTK组：4.1±1.0 vs UW组：3.0±0.5；P<.005）。
结论
UW溶液和HTK溶液在搏动灌注保存肾脏方面似乎具有相似的效果。HTK保存溶液可安全地与搏动保存联合用于肾脏同种异体移植物的冷藏。
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