Agarwal Avinash, Murdock Philip, Fridell Jonathan A
Department of Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Transplantation. 2006 Feb 15;81(3):480-2. doi: 10.1097/01.tp.0000196724.89757.79.
Although University of Wisconsin (UW) solution is the standard preservation solution for organ transplantation, Histidine-Tryptophan Ketogluatarate (HTK) solution has been increasingly used. This study compared HTK or UW for cold static storage of kidney allografts. In all, 149 renal transplants were performed with cold ischemic times (CI) greater than 16 hr (UW 87, HTK 62) and a subset analysis was performed with CI over 24 hr (HTK 31, UW 38). Data from receiving renal transplant centers focused on delayed graft function (DGF), patient and allograft survival. In CI greater than 16 hr, graft and patient survival were comparable. HTK cohort had lower DGF. In CI greater than 24 hr, there was no difference in patient survival, a trend towards improved graft survival in HTK, and decreased rate of DGF in HTK. This data suggests that UW and HTK have at least similar efficacy in kidney preservation at longer ischemic times.
尽管威斯康星大学（UW）溶液是器官移植的标准保存溶液，但组氨酸-色氨酸-酮戊二酸（HTK）溶液的使用越来越多。本研究比较了HTK溶液和UW溶液对同种异体肾移植的冷静态保存效果。总共进行了149例肾移植手术，冷缺血时间（CI）大于16小时（UW组87例，HTK组62例），并对CI超过24小时的患者进行了亚组分析（HTK组31例，UW组38例）。来自接受肾移植中心的数据集中在移植肾功能延迟恢复（DGF）、患者和移植肾存活率方面。在CI大于16小时的患者中，移植肾和患者的存活率相当。HTK组的DGF发生率较低。在CI大于24小时的患者中，患者存活率无差异，HTK组移植肾存活率有改善趋势，且HTK组DGF发生率降低。该数据表明，在较长缺血时间下，UW溶液和HTK溶液在肾脏保存方面至少具有相似的效果。
