Becker Thomas, Ringe Bastian, Nyibata Miguel, Meyer zu Vilsendorf Andreas, Schrem Harald, Lück Rainer, Neipp Michael, Klempnauer Jürgen, Bektas Hueseyin
Department of General, Visceral, and Transplant Surgery, Medical School of Hannover, Hannover, Germany.
JOP. 2007 May 9;8(3):304-11.
In clinical pancreas transplantation the choice of preservation solution may have an impact on graft pancreatitis. Experience with histidine-tryptophan-ketoglutarate (HTK) is still limited whereas University of Wisconsin (UW) solution is currently the preferred perfusate worldwide.
The aim of this study was to analyze our experience with HTK in pancreas transplantation.
In a retrospective analysis, data from 95 primary simultaneous pancreas-kidney transplantations were reviewed. The use of HTK (n=48) and UW (n=47) solution was stratified into two groups.
Patient/graft survival and early graft function were compared.
No significant differences between 1, 3 and 12 month patient survival (HTK: 97.9%, 97.9%, and 95.7% vs. UW: 95.7%, 89.4%, and 89.4%, respectively), and pancreas graft survival (HTK: 87.5%, 87.5%, and 85.4% vs. UW: 87.0%, 82.6%, and 82.6%, respectively) were detected. Higher values for peak lipase were observed on day 1 in the HTK group (not reaching significance: P=0.131) whereas no differences were noted for amylase and C-reactive protein.
HTK is clinically comparable to UW. Both solutions have been shown to be safe for pancreas preservation. Successful pancreas transplantation depends on many factors such as donor and recipient factors, but skilled organ procurement techniques, organ preservation, and transplant experience in this field is mandatory. The choice of organ preservation solution is only one point in this context.
在临床胰腺移植中，保存液的选择可能会对移植胰腺胰腺炎产生影响。组氨酸 - 色氨酸 - 酮戊二酸（HTK）溶液的使用经验仍然有限，而威斯康星大学（UW）溶液是目前全球首选的灌注液。
本研究的目的是分析我们在胰腺移植中使用HTK溶液的经验。
在一项回顾性分析中，回顾了95例初次同期胰腺 - 肾脏移植的数据。将HTK溶液（n = 48）和UW溶液（n = 47）的使用分为两组。
比较患者/移植物存活率和早期移植物功能。
在1个月、3个月和12个月的患者存活率（HTK组分别为97.9%、97.9%和95.7%，UW组分别为95.7%、89.4%和89.4%）以及胰腺移植物存活率（HTK组分别为87.5%、87.5%和85.4%，UW组分别为87.0%、82.6%和82.6%）方面未检测到显著差异。HTK组在第1天观察到更高的峰值脂肪酶值（无统计学意义：P = 0.131），而淀粉酶和C反应蛋白方面未观察到差异。
HTK在临床上与UW相当。两种溶液已被证明对胰腺保存是安全的。成功的胰腺移植取决于许多因素，如供体和受体因素，但熟练的器官获取技术、器官保存以及该领域的移植经验是必不可少的。在这种情况下，器官保存溶液的选择只是其中一点。
