Takemura N U
Department of Neurobiology, the University of Tokyo Graduate School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
Neuroscience. 2005;134(1):121-32. doi: 10.1016/j.neuroscience.2005.04.033.
Persistent neuron production in the adult CNS (adult neurogenesis) has been implicated in various brain functions such as learning/memory and mood control. Despite the widespread occurrence of neural stem/progenitor cells, active adult neurogenesis has been established only in two restricted regions. We explored in this study a previously overlooked neurogenic region in the adult rat brain and detected the evidence of neuron production within the subcortical white matter. Dividing Pax6- and Olig2-positive neural progenitor cells continually gave rise to doublecortin-positive new neurons in this region. However, the vast majority of newborn neurons were lost within a week of their birth. Accumulated apoptotic cells indicated the ongoing cell death in this area. In addition to providing the evidence of newborn cell migration to the hippocampus, these results suggest that cell genesis, death, and migration persist in a restricted subregion of the adult white matter.
成体中枢神经系统中持续的神经元生成（成体神经发生）与多种脑功能有关，如学习/记忆和情绪控制。尽管神经干细胞/祖细胞广泛存在，但活跃的成体神经发生仅在两个受限区域被证实。在本研究中，我们探索了成年大鼠脑中一个先前被忽视的神经发生区域，并在皮质下白质中检测到了神经元生成的证据。在该区域，分裂的Pax6和Olig2阳性神经祖细胞持续产生双皮质素阳性的新神经元。然而，绝大多数新生神经元在出生后一周内就消失了。累积的凋亡细胞表明该区域正在发生细胞死亡。除了提供新生细胞迁移至海马体的证据外，这些结果还表明，细胞生成、死亡和迁移在成体白质的一个受限子区域持续存在。
