Clark Danielle V, Mammen Mammen P, Nisalak Ananda, Puthimethee Virat, Endy Timothy P
Department of Virology, United States Army Medical Component, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand.
Am J Trop Med Hyg. 2005 Jun;72(6):786-91.
Dengue fever and dengue hemorrhagic fever constitute a substantial health burden on the population in Thailand. In this study, the impact of symptomatic dengue virus infection on the families of patients hospitalized at the Kamphaeng Phet Provincial Hospital with laboratory-confirmed dengue in 2001 was assessed, and the disability-adjusted life years (DALYs) lost for fatal and non-fatal cases of dengue were calculated using population level data for Thailand. When we accounted for the direct cost of hospitalization, indirect costs due to loss of productivity, and the average number of persons infected per family, we observed a financial loss of approximately US$61 per family, which is more than the average monthly income in Thailand. The DALYs were calculated using select results from a family level survey, and resulted in an estimated 427 DALYs/million population in 2001. This figure is of the same order of magnitude as the impact of several diseases currently given priority in southeast Asia, such as the tropical cluster (trypanosomiasis, Chagas disease, schistosomiasis, leishmaniasis, lymphatic filariasis, and onchocerciasis), malaria, meningitis, and hepatitis. These results indicate that dengue prevention, control, and research should be considered equally important as that of diseases currently given priority.
登革热和登革出血热给泰国民众带来了沉重的健康负担。在本研究中，评估了2001年在甘烹碧府医院住院的实验室确诊登革热患者的有症状登革病毒感染对其家庭的影响，并利用泰国的人口水平数据计算了登革热致死和非致死病例所损失的伤残调整生命年（DALYs）。当我们考虑住院的直接费用、生产力损失导致的间接费用以及每个家庭的平均感染人数时，我们发现每个家庭的经济损失约为61美元，这超过了泰国的平均月收入。DALYs是根据家庭层面调查的选定结果计算得出的，2001年估计为每百万人口427个DALYs。这个数字与东南亚目前优先关注的几种疾病的影响程度相当，如热带病群组（锥虫病、恰加斯病、血吸虫病、利什曼病、淋巴丝虫病和盘尾丝虫病）、疟疾、脑膜炎和肝炎。这些结果表明，登革热的预防、控制和研究应被视为与目前优先关注的疾病同等重要。
