Baker M R, Das M, Isaacs J, Fawcett P R W, Bates D
Department of Neurology, Royal Victoria Infirmary Queen Victoria Road, Newcastle upon Tyne NE1 4LP, UK.
J Neurol Neurosurg Psychiatry. 2005 Jul;76(7):999-1001. doi: 10.1136/jnnp.2004.051144.
This case report is about the novel use of the anti-CD20 antibody, rituximab, in the treatment of a 41 year old woman with stiff person syndrome. She was admitted to hospital as an emergency with prolonged and painful extensor spasms affecting the neck and back, arms, and legs. The disease had progressed despite a favourable initial response to conventional treatment with intravenous immunoglobulin and cytotoxics. Treatment with rituximab induced a lasting clinical remission.
本病例报告介绍了抗CD20抗体利妥昔单抗在治疗一名41岁僵人综合征女性患者中的新应用。她因颈部、背部、手臂和腿部持续性疼痛性伸肌痉挛而紧急入院。尽管最初对静脉注射免疫球蛋白和细胞毒性药物的常规治疗反应良好，但病情仍在进展。利妥昔单抗治疗诱导了持久的临床缓解。
