Horiuchi Kazuhiro, Maruo Yasunori, Matsuoka Satomi
Department of Neurology, Hakodate City Hospital, Japan.
Department of Hematology, Hakodate City Hospital, Japan.
Intern Med. 2018 Nov 15;57(22):3313-3316. doi: 10.2169/internalmedicine.1043-18. Epub 2018 Jul 6.
We herein report the case of stiff-person syndrome in a 73-year-old woman. She experienced episodes of painful muscle spasms and was admitted to another hospital. She was diagnosed with Waldenström macroglobulinemia. She showed improvement in muscle spasms post-chemotherapy, which was discontinued due to pancytopenia. Six months later, she was admitted to our hospital for repeated whole-body muscle spasms, at which point she was diagnosed with stiff-person syndrome. An anti-glutamic acid decarboxylase antibody text was negative. Her muscle spasms disappeared after the administration of corticosteroids and rituximab. Stiff-person syndrome may develop with Waldenström macroglobulinemia. In the present case, corticosteroids and rituximab provided effective treatment.
我们在此报告一例73岁女性的僵人综合征病例。她经历了疼痛性肌肉痉挛发作，并入住了另一家医院。她被诊断为华氏巨球蛋白血症。化疗后她的肌肉痉挛有所改善，但因全血细胞减少而停药。六个月后，她因反复全身肌肉痉挛入住我院，此时被诊断为僵人综合征。抗谷氨酸脱羧酶抗体检测为阴性。给予皮质类固醇和利妥昔单抗后，她的肌肉痉挛消失。僵人综合征可能与华氏巨球蛋白血症并发。在本病例中，皮质类固醇和利妥昔单抗提供了有效的治疗。
