中国维吾尔族的Y染色体短串联重复序列单倍型
Y-chromosomal STR haplotypes in Chinese Uigur ethnic group.
作者信息
Zhu Bo Feng, Wang Zhen Yuan, Yang Chun Hua, Li Xiao Song, Zhu Jun, Yang Guang, Huang Ping, Liu Yao
机构信息
The Key Laboratory of Environment and Gene Related to Diseases, Ministry of Education, Xi'an Jiaotong University, 710061, Shaanxi, People's Republic of China.
出版信息
Int J Legal Med. 2005 Sep;119(5):306-9. doi: 10.1007/s00414-005-0549-5. Epub 2005 Jun 18.
We have already coamplified minimal haplotypes (DYS19, DYS389I, DYS389II, DYS390, DYS391, DYS392, DYS393, DYS385I/II), two additional loci, namely, DYS438, DYS439, and Amelogenin, in a single PCR using the Y-PLEX 12 kit. We investigated 107 unrelated male individuals from the Uigur ethnic group and studied the allelic frequency distribution and haplotype diversity of 11 Y-chromosomal STRs. A number of 43 alleles (nine STR loci) and 27 phenotypes (including DYS385) were detected, with frequencies ranging from 0.0092 to 0.6296. A total of 103 haplotypes were identified, among which 99 were individual-specific and four haplotypes were found twice. The haplotype diversity for these 12 Y-STR loci was 0.9993.
我们已经使用Y-PLEX 12试剂盒，通过单一聚合酶链式反应（PCR）共同扩增了最小单倍型（DYS19、DYS389I、DYS389II、DYS390、DYS391、DYS392、DYS393、DYS385I/II）以及另外两个基因座，即DYS438、DYS439和牙釉蛋白基因（Amelogenin）。我们调查了107名维吾尔族无关男性个体，研究了11个Y染色体短串联重复序列（STR）的等位基因频率分布和单倍型多样性。共检测到43个等位基因（9个STR基因座）和27种表型（包括DYS385），频率范围为0.0092至0.6296。总共鉴定出103种单倍型，其中99种是个体特异性的，4种单倍型出现了两次。这12个Y-STR基因座的单倍型多样性为0.9993。
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