Ott Ulrich, Reuter Martin, Hennig Juergen, Vaitl Dieter
Center for Psychobiology and Behavioral Medicine, University of Giessen, Otto-Behaghel-Street 10F, 35394 Giessen, Germany.
Am J Med Genet B Neuropsychiatr Genet. 2005 Aug 5;137B(1):29-32. doi: 10.1002/ajmg.b.30197.
Absorption represents a disposition to experience altered states of consciousness characterized by intensively focused attention. It is correlated with hypnotic susceptibility and includes phenomena ranging from vivid perceptions and imaginations to mystical experiences. Based on the assumption that drug-induced and naturally occurring mystical experiences share common neural mechanisms, we hypothesized that Absorption is influenced by the T102C polymorphism affecting the 5-HT2a receptor, which is known to be an important target site of hallucinogens like LSD. Based on the pivotal role ascribed to the prefrontal executive control network for absorbed attention and positive symptoms in schizophrenia, it was further hypothesized that Absorption is associated with the VAL158MET polymorphism of the catechol-O-methyltransferase (COMT) gene affecting the dopaminergic neurotransmitter system. The Tellegen Absorption Scale was administered to 336 subjects (95 male, 241 female). Statistical analysis revealed that the group with the T/T genotype of the T102C polymorphism, implying a stronger binding potential of the 5-HT2a receptor, indeed had significantly higher Absorption scores (F = 10.00, P = 0.002), while no main effect was found for the COMT polymorphism. However, the interaction between T102C and COMT genotypes yielded significance (F = 3.89; P = 0.049), underlining the known functional interaction between the 5-HT and the dopaminergic system. These findings point to biological foundations of the personality trait of Absorption.
专注性表现为一种易于体验意识改变状态的倾向，其特征为注意力高度集中。它与催眠易感性相关，包括从生动的感知和想象到神秘体验等一系列现象。基于药物诱发的和自然发生的神秘体验具有共同神经机制这一假设，我们推测专注性受影响5 - HT2a受体的T102C多态性影响，已知5 - HT2a受体是诸如麦角酸二乙酰胺（LSD）等致幻剂的重要靶点。基于前额叶执行控制网络在精神分裂症的专注性注意力和阳性症状中所起的关键作用，我们进一步推测专注性与影响多巴胺能神经递质系统的儿茶酚 - O - 甲基转移酶（COMT）基因的VAL158MET多态性有关。对336名受试者（95名男性，241名女性）进行了泰勒根专注性量表测试。统计分析显示，T102C多态性的T/T基因型组，意味着5 - HT2a受体具有更强的结合潜力，其专注性得分确实显著更高（F = 10.00，P = 0.002），而未发现COMT多态性的主效应。然而，T102C和COMT基因型之间的相互作用具有显著性（F = 3.89；P = 0.049），突显了5 - HT与多巴胺能系统之间已知的功能相互作用。这些发现指向了专注性这一个性特质的生物学基础。
