诱导型克林霉素耐药葡萄球菌在烧伤患者中的分离。
Inducible Clindamycin Resistance among Staphylococci Isolated from Burn Patients.
机构信息
Department of Microbiology and Immunology, Faculty of Medicine, El-Fateh University for Medical Sciences.
出版信息
Libyan J Med. 2009 Sep 1;4(3):104-6. doi: 10.4176/090128.
Abstract
Clindamycin has been used successfully to treat pneumonia and soft-tissue infections caused by methicillin-resistant Staphylococcus aureus. However, inducible clindamycin resistance has been described as a cause of treatment failure of such infections. A total of 159 staphylococcal isolates from different clinical specimens from burn patients in Tripoli Burn Center were tested for inducible clindamycin resistance by the disk-diffusion induction test. Inducible clindamycin resistance was detected in 66.2% of 65 methicillin-resistant S. aureus isolates and in none of 55 methicillin-sensitive S. aureus, 10 methicillin-resistant coagulase negative staphylococci and 29 methicllin-sensitive coagulase negative staphylococci isolates. In our setting, clindamycin can be used for the treatment of infections due to staphylococci, but we recommend that staphylococci isolates, particularly methicillin-resistant S. aureus, are tested by the D-test before treatment.
摘要
克林霉素已成功用于治疗耐甲氧西林金黄色葡萄球菌引起的肺炎和软组织感染。然而，诱导性克林霉素耐药性已被描述为导致此类感染治疗失败的原因。来自的黎波里烧伤中心不同临床标本的 159 株葡萄球菌分离株通过纸片扩散诱导试验检测诱导性克林霉素耐药性。在 65 株耐甲氧西林金黄色葡萄球菌分离株中，有 66.2%检测到诱导性克林霉素耐药性，而在 55 株甲氧西林敏感金黄色葡萄球菌、10 株耐甲氧西林凝固酶阴性葡萄球菌和 29 株甲氧西林敏感凝固酶阴性葡萄球菌分离株中均未检测到诱导性克林霉素耐药性。在我们的环境中，克林霉素可用于治疗由葡萄球菌引起的感染，但我们建议在治疗前使用 D 试验检测葡萄球菌分离株，特别是耐甲氧西林金黄色葡萄球菌。
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