钙、维生素D、磷的膳食摄入量与前列腺癌风险
Dietary intake of calcium, vitamin D, phosphorus and the risk of prostate cancer.
作者信息
Tavani Alessandra, Bertuccio Paola, Bosetti Cristina, Talamini Renato, Negri Eva, Franceschi Silvia, Montella Maurizio, La Vecchia Carlo
机构信息
Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, 20157 Milano, Italy.
出版信息
Eur Urol. 2005 Jul;48(1):27-33. doi: 10.1016/j.eururo.2005.03.023. Epub 2005 Apr 8.
OBJECTIVES
A relation of prostate cancer risk with calcium, vitamin D and phosphorus has been suggested, but remains controversial.
METHODS
A case-control study was conducted in Italy in 1991-2002. Cases were 1294 men with incident prostate cancer, and controls were 1451 men admitted to hospital for acute non-neoplastic diseases. Odds ratios (OR) and the corresponding 95% confidence intervals (CI) were estimated using unconditional multiple logistic regression.
RESULTS
Compared to the lowest one quintile of dietary calcium intake the OR was 1.18 for the highest, 1.01 for an increment of 622 mg/day of calcium, and 1.29 (95% CI 0.78-2.13) for 2000 mg/day or more of calcium. The OR of prostate cancer for the highest quintile of dietary intake of vitamin D and phosphorus were 1.33 and 1.20 respectively.
CONCLUSIONS
This study shows no material association of dietary intake of calcium, vitamin D and phosphorus with prostate cancer risk.
目的
已有研究表明前列腺癌风险与钙、维生素D和磷之间存在关联，但仍存在争议。
方法
1991年至2002年在意大利进行了一项病例对照研究。病例为1294例新发前列腺癌男性患者，对照为1451例因急性非肿瘤性疾病入院的男性患者。采用无条件多因素logistic回归估计比值比（OR）及相应的95%置信区间（CI）。
结果
与膳食钙摄入量最低的五分位数相比，最高五分位数的OR为1.18，钙摄入量每天增加622毫克时的OR为1.01，钙摄入量达到或超过2000毫克/天时的OR为1.29（95%CI 0.78 - 2.13）。膳食维生素D和磷摄入量最高五分位数的前列腺癌OR分别为1.33和1.20。
结论
本研究表明，膳食中钙、维生素D和磷的摄入量与前列腺癌风险无实质关联。
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