意大利的糖尿病与前列腺癌风险
Diabetes mellitus and the risk of prostate cancer in Italy.
作者信息
Tavani A, Gallus S, Bertuzzi M, Dal Maso L, Zucchetto A, Negri E, Franceschi S, Ramazzotti V, Montella M, La Vecchia C
机构信息
Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, 20157 Milan, Italy.
出版信息
Eur Urol. 2005 Mar;47(3):313-7; discussion 317. doi: 10.1016/j.eururo.2004.10.027. Epub 2005 Jan 6.
OBJECTIVE
We investigated the relation between diabetes and the risk of prostate cancer, as epidemiological results are controversial.
METHODS
A hospital-based case-control study was conducted in Italy between 1991 and 2002. Cases were 1294 men, aged <75 years, with incident histologically confirmed prostate cancer, and controls were 1451 men, aged <75 years, admitted to hospital for acute non-neoplastic diseases. Odds ratios (OR) and the corresponding 95% confidence intervals (CI) were estimated using unconditional multiple logistic regression models.
RESULTS
No material association between diabetes and prostate cancer was observed, with a multivariate OR of 1.02 (95%CI 0.75-1.40). Prostate cancer was not related to time since diagnosis of diabetes (OR 0.82 and 0.97 for <5 and >/=15 years since diagnosis respectively). The OR were respectively 1.63 (95%CI 0.70-3.81) and 0.96 (95%CI 0.68-1.34) in men diagnosed with diabetes at age <45 or >/=45 years. The risk estimates were similar across strata of age at interview, body mass index and, among cases, of Gleason score.
CONCLUSIONS
This study shows no material association between diabetes and prostate cancer risk.
目的
由于流行病学研究结果存在争议，我们对糖尿病与前列腺癌风险之间的关系进行了调查。
方法
1991年至2002年在意大利进行了一项基于医院的病例对照研究。病例为1294名年龄小于75岁、经组织学确诊为新发前列腺癌的男性，对照为1451名年龄小于75岁、因急性非肿瘤性疾病入院的男性。使用无条件多因素logistic回归模型估计比值比（OR）及相应的95%置信区间（CI）。
结果
未观察到糖尿病与前列腺癌之间存在实质性关联，多因素OR为1.02（95%CI 0.75 - 1.40）。前列腺癌与糖尿病诊断后的时间无关（诊断后<5年和≥15年的OR分别为0.82和0.97）。年龄<45岁或≥45岁时被诊断为糖尿病的男性，其OR分别为1.63（95%CI 0.70 - 3.81）和0.96（95%CI 0.68 - 1.34）。在访谈时的年龄、体重指数分层以及病例中的Gleason评分各层中，风险估计值相似。
结论
本研究表明糖尿病与前列腺癌风险之间不存在实质性关联。
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