Ambrosi Adriano, Antiochia Riccarda, Campanella Luigi, Dragone Roberto, Lavagnini Irma
Dipartimento di Chimica, Università La Sapienza, Rome, Italy.
J Hazard Mater. 2005 Jul 15;122(3):219-25. doi: 10.1016/j.jhazmat.2005.03.011. Epub 2005 Apr 18.
The electrochemical behaviour of acidic and neutral pharmaceutical active compounds (PhACs) was studied by cyclic voltammetry and pulse voltammetric techniques on mercury, carbon nanotube paste, carbon paste and gold electrodes. The best results, in terms of sensitivity, linearity range and detection limits, were obtained by differential pulse voltammetry (DPV) for ofloxacin (LOD 5.2 microM), differential pulse polarography (DPP) for clofibric acid (LOD 4.7 microM) and normal pulse voltammetry (NPV) for diclofenac (LOD 0.8 microM) and propranolol (LOD 0.5 microM). An enrichment step of approximately two orders of magnitude was performed by a solid-phase extraction procedure (SPE) in order to concentrate the samples. The developed method was optimized and tested on spiked river water samples.
采用循环伏安法和脉冲伏安技术，在汞电极、碳纳米管糊电极、碳糊电极和金电极上研究了酸性和中性药物活性化合物（PhACs）的电化学行为。就灵敏度、线性范围和检测限而言，通过差分脉冲伏安法（DPV）测定氧氟沙星（检测限为5.2微摩尔/升）、差分脉冲极谱法（DPP）测定氯贝酸（检测限为4.7微摩尔/升）、常规脉冲伏安法（NPV）测定双氯芬酸（检测限为0.8微摩尔/升）和普萘洛尔（检测限为0.5微摩尔/升）时获得了最佳结果。通过固相萃取程序（SPE）进行了约两个数量级的富集步骤，以浓缩样品。所开发的方法在加标河水样品上进行了优化和测试。
