来自几内亚蒲桃（桃金娘科）的抗菌三萜类化合物。

Antibacterial triterpenes from Syzygium guineense (Myrtaceae).

作者信息

Djoukeng J D, Abou-Mansour E, Tabacchi R, Tapondjou A L, Bouda H, Lontsi D

机构信息

Université of Neuchâtel, Institut de Chimie, av. Bellevaux 51, CH-2000 Neuchâtel, Switzerland.

出版信息

J Ethnopharmacol. 2005 Oct 3;101(1-3):283-6. doi: 10.1016/j.jep.2005.05.008.

DOI:10.1016/j.jep.2005.05.008

PMID:15967609

Abstract

Antibacterial bioassay-guided fractionation of Syzygium guineense leaf extracts afforded 10 triterpenes, namely betulinic acid 1, oleanolic acid 2, a mixture of 2-hydroxyoleanolic acid 3a, 2-hydroxyursolic acid 3b, arjunolic acid 4a, asiatic acid 4b, a mixture of terminolic acid 5a, 6-hydroxyasiatic acid 5b, and a mixture of arjunolic acid 28-beta-glucopyranosyl ester 6a and the asiatic acid 28-beta-glucopyranosyl ester 6b. Isolated compounds were submitted to an antibacterial assay system against gram-positive and -negative bacteria and human pathogen bacteria. Compounds 4a and 4b showed the most significant antibacterial activity against Escherichia coli, Bacillus subtilis and Shigella sonnei. The fraction 5a-5b was the least active, whereas compounds 1, 2 and the mixtures of 3a-3b and 6a-6b were inactive in the assays.

摘要

对几内亚蒲桃叶提取物进行抗菌生物测定引导的分级分离，得到了10种三萜类化合物，即桦木酸1、齐墩果酸2、2-羟基齐墩果酸3a、2-羟基熊果酸3b的混合物、阿江榄仁酸4a、积雪草苷4b、榄香醇酸5a、6-羟基积雪草苷5b的混合物，以及阿江榄仁酸28-β-葡萄糖苷酯6a和积雪草苷28-β-葡萄糖苷酯6b的混合物。将分离得到的化合物针对革兰氏阳性菌、革兰氏阴性菌和人类病原菌进行抗菌测定。化合物4a和4b对大肠杆菌、枯草芽孢杆菌和宋内志贺菌表现出最显著的抗菌活性。5a-5b部分活性最低，而化合物1、2以及3a-3b和6a-6b的混合物在测定中无活性。