Beckett Charmagne G, Kosasih Herman, Faisal Indra, Tan Ratna, Widjaja Susana, Listiyaningsih Erlin, Ma'roef Chairin, Wuryadi Suharyono, Bangs Michael J, Samsi Tatang K, Yuwono Djoko, Hayes Curtis G, Porter Kevin R
Viral Diseases Program, U.S. Naval Medical Research Unit No. 2, Jakarta, Indonesia.
Am J Trop Med Hyg. 2005 Jun;72(6):777-82.
A two-year study using a cluster investigation method was conducted in West Jakarta, Indonesia to demonstrate the detection of dengue cases prior to onset of clinical illness. The clusters consisted of family members and neighbors of 53 hospitalized dengue index cases. Among 785 adult and child volunteers enrolled, 17 (2.2%) post-enrollment dengue (PED) infections were identified. Eight PED cases were asymptomatic and nine were symptomatic. Symptomatic cases included eight with dengue fever and one with dengue hemorrhagic fever (DHF) (grade II). Among the eight asymptomatic PED cases, viremia was detected in two. Eleven volunteers had acute dengue infections at the time of enrollment. Four of the 11 developed DHF, resulting in a total of five DHF cases detected during the investigation. This study design can serve as a benchmark for future investigations that seek to define early immunologic events following dengue infections that contribute to the development of DHF.
在印度尼西亚雅加达西部开展了一项为期两年的研究，采用整群调查方法来证明在临床疾病发作之前检测登革热病例。这些群组由53例住院登革热索引病例的家庭成员和邻居组成。在785名登记的成人和儿童志愿者中，确定了17例（2.2%）登记后登革热（PED）感染。8例PED病例无症状，9例有症状。有症状的病例包括8例登革热和1例登革出血热（DHF，II级）。在8例无症状PED病例中，2例检测到病毒血症。11名志愿者在登记时患有急性登革热感染。11例中有4例发展为DHF，调查期间共检测到5例DHF病例。本研究设计可作为未来调查的基准，这些调查旨在确定登革热感染后导致DHF发生的早期免疫事件。
