Mahboob M, Rahman M F, Grover P
Toxicology Unit, Biology Division, Indian Institute of Chemical Technology, Tarnaka, Habshiguda, Hyderabad 500007, India.
Singapore Med J. 2005 Jul;46(7):322-4.
The depletion of defensive body chemicals called antioxidants may increase the risk of complications from the most common form of diabetes mellitus. This study aims to evaluate blood serum lipid peroxidation product (malondialdehyde), an antioxidant, in non-insulin dependent male and female type 2 diabetic patients.
Blood serum samples were collected from the diabetic patients and non-diabetic healthy controls. Malondialdehyde (MDA) level, which is an index of endogenous lipid peroxidation, reduced glutathione and protein content of the serum were estimated.
A significant elevation in MDA level and decrease in glutathione and protein content was observed in both male and female diabetic patients in comparison to non-diabetic controls.
Our findings indicate that the increase in the lipid peroxidation product MDA and decline in glutathione-dependent antioxidant defences may appear early in non-insulin dependent type 2 diabetes mellitus patients before the development of secondary complications.
被称为抗氧化剂的防御性身体化学物质的消耗可能会增加最常见形式的糖尿病并发症的风险。本研究旨在评估非胰岛素依赖型2型糖尿病男性和女性患者血清中的脂质过氧化产物（丙二醛），一种抗氧化剂。
从糖尿病患者和非糖尿病健康对照者中采集血清样本。估计丙二醛（MDA）水平，这是内源性脂质过氧化的指标，以及血清中还原型谷胱甘肽和蛋白质含量。
与非糖尿病对照组相比，男性和女性糖尿病患者的MDA水平均显著升高，谷胱甘肽和蛋白质含量降低。
我们的研究结果表明，脂质过氧化产物MDA的增加和依赖谷胱甘肽的抗氧化防御能力的下降可能在非胰岛素依赖型2型糖尿病患者继发并发症出现之前就已早期出现。
