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The structure of mytilan, a bioglycan-immunomodulator isolated from the mussel Crenomytilus grayanus.

作者信息

Ovodova R G, Glazkova V E, Mikheyskaya L V, Molchanova V I, Isakov V V, Ovodov Y S, Fernandez Molina L E

机构信息

Pacific Institute of Bioorganic Chemistry, U.S.S.R. Academy of Sciences, Vladivostok.

出版信息

Carbohydr Res. 1992 Jan;223:221-6. doi: 10.1016/0008-6215(92)80018-v.

DOI:10.1016/0008-6215(92)80018-v
PMID:1596920
Abstract

Mytilan, isolated from the mantle of the mussel Crenomytilus grayanus and which possesses high immunomodulating activity, is a non-covalently linked complex of a polysaccharide (95%) and protein (5%) with lectin activities. Chromatography of mytilan on agarose separated the polysaccharide and protein constituents. The protein appeared to have the lectin properties. Methylation analysis, Smith degradation, digestion with alpha-amylase, and 13C-n.m.r. spectroscopy showed the polysaccharide to be a glycogen-like alpha-D-glucan.

摘要

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