Michankin B N, Chevchenko L A, Asseeva L E
Institut antipesteux, Rostov-Don, URSS.
Bull Soc Pathol Exot. 1992;85(1):17-21.
Biological effect of homogenous preparation of Y. pestis adenylate cyclase on eucaryotic cells was studied. Adenylate cyclase, added (7.5 x 10(8) g/ml) to guinea pig macrophages lowers the level of chemiluminescence to 50-70%, has an appreciable cytotoxic effect on peritoneal macrophages and suppresses phosphorylation processes of leucocyte proteins from white mice. The experimental results obtained allow to suggest Y. pestis adenylate cyclase to be a pathogenic factor, contributing to the development of plague infection.
研究了鼠疫耶尔森氏菌腺苷酸环化酶的纯制剂对真核细胞的生物学效应。向豚鼠巨噬细胞中添加（7.5×10⁸克/毫升）腺苷酸环化酶可使化学发光水平降低50%至70%，对腹膜巨噬细胞有明显的细胞毒性作用，并抑制小白鼠白细胞蛋白质的磷酸化过程。所获得的实验结果表明，鼠疫耶尔森氏菌腺苷酸环化酶是一种致病因素，有助于鼠疫感染的发展。
