Hagendorens M M, Bridts C H, Lauwers K, van Nuijs S, Ebo D G, Vellinga A, De Clerck L S, Van Bever H P, Weyler J J, Stevens W J
Department of Paediatrics, University of Antwerp, Antwerp, Belgium.
Clin Exp Allergy. 2005 Jun;35(6):733-40. doi: 10.1111/j.1365-2222.2005.02254.x.
To evaluate the influence of perinatal environmental factors on early sensitization, atopic dermatitis and wheezing during the first year.
Information on pregnancy-related factors, parental atopic history, environmental factors and the clinical course of the infant until age one was gathered by questionnaires, as part of a prospective birth cohort study (Prospective study on the Influence of Perinatal factors on the Occurrence of asthma and allergies [PIPO-study]). Quantification of total and specific IgE was performed in 810 children and their parents.
Early sensitization was found in 107/810 (13%) of the infants. Multiple regression analysis showed that specific IgE in fathers was a risk factor for early sensitization in their daughters (adjusted odds ratios (OR(adj)) 2.21 (95% confidence interval (CI) 1.10-4.49); P=0.03), whereas in boys, day care attendance was shown to be protective for early sensitization (OR(adj) 0.38 (95% CI 0.20-0.71); P=0.001). Atopic dermatitis occurred in 195/792 infants (25%). Specific IgE in the mother (OR(adj) 1.52 (95% CI 1.06-2.19); P=0.02) and in the infant (OR(adj) 4.20 (95% CI 2.63-6.68); P<0.001) were both risk factors for the occurence of atopic dermatitis, whereas postnatal exposure to cats was negatively associated with atopic dermatitis (OR(adj) 0.68 (0.47-0.97); P=0.03). Postnatal exposure to cigarette smoke (OR(adj) 3.31 (95% CI 1.79-6.09); P<0.001) and day care attendance (OR(adj) 1.96 (95% CI 1.18-3.23); P=0.009) were significantly associated with early wheezing, which occurred in 25% (197/795) of the infants.
The effect of paternal sensitization and day care attendance on sensitization is gender dependent. Maternal sensitization predisposes for atopic dermatitis, whereas postnatal exposure to cats had a protective effect.
评估围产期环境因素对婴儿出生后第一年早期致敏、特应性皮炎和喘息的影响。
作为一项前瞻性出生队列研究（围产期因素对哮喘和过敏发生的影响的前瞻性研究 [PIPO 研究]）的一部分，通过问卷调查收集了与妊娠相关的因素、父母的特应性病史、环境因素以及婴儿至一岁时的临床病程信息。对810名儿童及其父母进行了总IgE和特异性IgE的定量检测。
在810名婴儿中有107名（13%）出现早期致敏。多元回归分析显示，父亲的特异性IgE是其女儿早期致敏的危险因素（校正比值比（OR(adj)）2.21（95%置信区间（CI）1.10 - 4.49）；P = 0.03），而对于男孩，入托对早期致敏有保护作用（OR(adj) 0.38（95% CI 0.20 - 0.71）；P = 0.001）。792名婴儿中有195名（25%）发生特应性皮炎。母亲（OR(adj) 1.52（95% CI 1.06 - 2.19）；P = 0.02）和婴儿（OR(adj) 4.20（95% CI 2.63 - 6.68）；P < 0.001）的特异性IgE都是特应性皮炎发生的危险因素，而出生后接触猫与特应性皮炎呈负相关（OR(adj) 0.68（0.47 - 0.97）；P = 0.03）。出生后接触香烟烟雾（OR(adj) 3.31（95% CI 1.79 - 6.09）；P < 0.001）和入托（OR(adj) 1.96（95% CI 1.18 - 3.23）；P = 0.009）与早期喘息显著相关，25%（197/795）的婴儿出现早期喘息。
父亲致敏和入托对致敏的影响存在性别差异。母亲致敏易导致特应性皮炎，而出生后接触猫具有保护作用。
