Dom Sandra, Droste Jos H J, Sariachvili Manana A, Hagendorens Margo M, Bridts Chris H, Stevens Wim J, Desager Kristine N, Wieringa Marjan H, Weyler Joost J
Department of Epidemiology and Community Medicine, University of Antwerp, Universiteitsplein 1 B-2610, Antwerp, Belgium.
Pediatr Allergy Immunol. 2009 Aug;20(5):438-47. doi: 10.1111/j.1399-3038.2008.00834.x. Epub 2009 Feb 10.
Several studies have investigated the association between socioeconomic status and the occurrence of allergies. Nevertheless, the results remain contradictory. The aim of this study was to evaluate the associations between parental education and the occurrence of atopic sensitization, recurrent wheezing and eczema during the first year of life, differentiating between atopic and non-atopic disorders based on specific serum IgE. We conducted an aetiological study in 690 children, based on a prospective birth cohort project in which environmental and health information was gathered using questionnaires. At the age of 1 yr a blood sample was taken for quantification of specific IgE. Adjusted odds ratios and 95% confidence intervals were computed as measures of association between the outcomes and parental education. Parental educational level was positively associated with the occurrence of atopic sensitization (OR: 2.1; 95% CI: 1.0-4.4) and eczema (OR: 1.9; 95% CI: 1.1-3.4), but negatively with the occurrence of recurrent wheezing (OR: 0.4; 95% CI: 0.2-0.8) in the first year of life. Atopic recurrent wheezing was positively associated with the education of the parents, whereas non-atopic recurrent wheezing was negatively associated. When maternal and paternal education were considered separately, only maternal education had a significant influence. Our results suggest that aspects associated with a high maternal educational level may play an important role in the development of atopic disorders.
多项研究调查了社会经济地位与过敏症发生之间的关联。然而，结果仍然相互矛盾。本研究的目的是评估父母教育程度与出生后第一年特应性致敏、反复喘息和湿疹发生之间的关联，并根据特异性血清IgE区分特应性和非特应性疾病。我们基于一项前瞻性出生队列项目对690名儿童进行了病因学研究，该项目通过问卷调查收集环境和健康信息。在1岁时采集血样以定量特异性IgE。计算调整后的比值比和95%置信区间，作为结果与父母教育程度之间关联的度量。父母教育水平与出生后第一年特应性致敏（比值比：2.1；95%置信区间：1.0 - 4.4）和湿疹（比值比：1.9；95%置信区间：1.1 - 3.4）的发生呈正相关，但与反复喘息的发生呈负相关（比值比：0.4；95%置信区间：0.2 - 0.8）。特应性反复喘息与父母教育程度呈正相关，而非特应性反复喘息则呈负相关。当分别考虑母亲和父亲的教育程度时，只有母亲的教育程度有显著影响。我们的结果表明，与母亲高教育水平相关的因素可能在特应性疾病的发展中起重要作用。
