Brunekreef B, van Strien R, Pronk A, Oldenwening M, de Jongste J C, Wijga A, Kerkhof M, Aalberse R C
Institute for Risk Assessment Sciences, Utrecht University, Utrecht, the Netherlands.
Allergy. 2005 Aug;60(8):1083-6. doi: 10.1111/j.1398-9995.2005.00881.x.
The PIAMA study evaluates whether application of mite impermeable mattress covers reduces exposure to mite allergen sufficiently to reduce the incidence of asthma and mite allergy. The study started in 1996. Baseline measurements of mite allergen levels were conducted on mattresses of newborn children and their parents, mostly in 1997. Mite allergen levels were surprisingly low in this study compared with previous studies among school children and infants. Mite allergen levels were measured again on mattresses in the PIAMA study in the years 2000/2001 when the children were 4 years old, and in a new study among 6-12 year old school children conducted in the fall of 2001. Data on winter climate were collected as well. In the winters of 1995/1996 and 1996/1997, which preceded and coincided with the PIAMA baseline measurements, temperatures had been extremely low, and precipitation had been extremely low as well. It is likely that these unusual winter weather conditions affected the baseline allergen levels in the PIAMA study so that the effect of the planned intervention (mite impermeable mattress covers) was considerably smaller than it could have been.
PIAMA研究旨在评估使用防螨床垫罩是否能充分降低对螨过敏原的暴露，从而降低哮喘和螨过敏的发病率。该研究始于1996年。主要在1997年对新生儿及其父母床垫上的螨过敏原水平进行了基线测量。与之前针对学童和婴儿的研究相比，本研究中的螨过敏原水平出奇地低。在2000/2001年孩子们4岁时，对PIAMA研究中的床垫再次测量了螨过敏原水平，并于2001年秋季在一项针对6至12岁学童的新研究中进行了测量。同时还收集了冬季气候数据。在PIAMA基线测量之前的1995/1996年冬季以及与之同期的1996/1997年冬季，气温极低，降水量也极低。很可能这些异常的冬季天气状况影响了PIAMA研究中的基线过敏原水平，以至于计划中的干预措施（防螨床垫罩）的效果比原本可能达到的效果要小得多。
