复方草药制剂Diasulin对四氧嘧啶诱导的高血糖大鼠的降血脂及抗过氧化作用
Antihyperlipidemic and antiperoxidative effect of Diasulin, a polyherbal formulation in alloxan induced hyperglycemic rats.
作者信息
Saravanan Ramalingam, Pari Leelavinothan
机构信息
Department of Biochemistry, Faculty of Science, Annamalai University, Annamalai Nagar, Tamil Nadu-608 002, India.
出版信息
BMC Complement Altern Med. 2005 Jun 22;5:14. doi: 10.1186/1472-6882-5-14.
BACKGROUND
This study was undertaken to investigation the effect of Diasulin, a poly herbal drug composed of ethanolic extract of ten medicinal plants on blood glucose, plasma insulin, tissue lipid profile, and lipidperoxidation in alloxan induced diabetes.
METHODS
Ethanolic extract of Diasulin a, poly herbal drug was administered orally (200 mg/kg body weight) for 30 days. The different doses of Diasulin on blood glucose and plasma insulin in diabetic rats were studied and the levels of lipid peroxides [TBARS, and hydroperoxide] and tissue lipids [cholesterol, triglyceride, phospholipides and free fatty acids] were also estimated in alloxan induced diabetic rats. The effects were compared with glibenclamide.
RESULT
Treatment with Diasulin and glibenclamide resulted in a significant reduction of blood glucose and increase in plasma insulin. Diasulin also resulted in a significant decrease in tissue lipids and lipid peroxide formation. The effect produced by Diasulin was comparable with that of glibenclamide.
CONCLUSION
The decreased lipid peroxides and tissue lipids clearly showed the antihyperlipidemic and antiperoxidative effect of Diasulin apart from its antidiabetic effect.
背景
本研究旨在调查一种由十种药用植物乙醇提取物组成的复方草药药物——迪亚苏林（Diasulin）对四氧嘧啶诱导糖尿病大鼠的血糖、血浆胰岛素、组织脂质谱和脂质过氧化的影响。
方法
口服给予复方草药药物迪亚苏林a的乙醇提取物（200毫克/千克体重），持续30天。研究了不同剂量的迪亚苏林对糖尿病大鼠血糖和血浆胰岛素的影响，并测定了四氧嘧啶诱导糖尿病大鼠的脂质过氧化物[硫代巴比妥酸反应物（TBARS）和氢过氧化物]以及组织脂质[胆固醇、甘油三酯、磷脂和游离脂肪酸]水平。将这些效果与格列本脲进行比较。
结果
用迪亚苏林和格列本脲治疗均导致血糖显著降低和血浆胰岛素增加。迪亚苏林还导致组织脂质和脂质过氧化物形成显著减少。迪亚苏林产生的效果与格列本脲相当。
结论
脂质过氧化物和组织脂质的减少清楚地表明，迪亚苏林除了具有抗糖尿病作用外，还具有抗高血脂和抗过氧化作用。
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