Latha M, Pari L
Department of Biochemistry, Faculty of Science, Annamalai University, Annamalai Nagar, Tamil Nadu, India.
J Med Food. 2003 Winter;6(4):379-86. doi: 10.1089/109662003772519958.
In light of evidence that diabetes mellitus is associated with oxidative stress and altered antioxidant status, we investigated the effect of Scoparia dulcis plant extracts (SPEt) (aqueous, ethanolic, and chloroform) in streptozotocin diabetic rats. Significant increases in the activities of insulin, superoxide dismutase, catalase, glutathione peroxidase, glutathione-S-transferase, reduced glutathione, vitamin C, and vitamin E were observed in liver, kidney, and brain on treatment with SPEt. In addition, the treated groups also showed significant decreases in blood glucose, thiobarbituric acid-reactive substances, and hydroperoxide formation in tissues, suggesting its role in protection against lipid peroxidation-induced membrane damage. Thus, the results of the present study indicate that extracts of S. dulcis, especially the aqueous extract, showed a modulatory effect by attenuating the above lipid peroxidation in streptozotocin diabetes.
鉴于有证据表明糖尿病与氧化应激及抗氧化状态改变有关，我们研究了甜叶（Scoparia dulcis）植物提取物（SPEt）（水提取物、乙醇提取物和氯仿提取物）对链脲佐菌素诱导的糖尿病大鼠的影响。在用SPEt治疗后，肝脏、肾脏和大脑中胰岛素、超氧化物歧化酶、过氧化氢酶、谷胱甘肽过氧化物酶、谷胱甘肽-S-转移酶、还原型谷胱甘肽、维生素C和维生素E的活性显著增加。此外，治疗组的血糖、硫代巴比妥酸反应性物质和组织中过氧化氢的形成也显著降低，表明其在预防脂质过氧化诱导的膜损伤中发挥作用。因此，本研究结果表明，甜叶提取物，尤其是水提取物，通过减轻链脲佐菌素糖尿病中的上述脂质过氧化作用，显示出调节作用。
