Libra Massimo, Gasparotto Daniela, Gloghini Annunziata, Navolanic Patrick Michael, De Re Valli, Carbone Antonino
Department of Biomedical Sciences, University of Catania, Italy.
Front Biosci. 2005 Sep 1;10:2460-71. doi: 10.2741/1710.
Several infectious agents have been associated with development of lymphoproliferative disorders. Among these is hepatitis C virus (HCV), which infects more than 200 million people worldwide. HCV infection has been linked to progression of type II mixed cryoglobulinemia (MC) syndrome and has also been suggested to contribute to development of B-cell non-Hodgkin's lymphoma (NHL). Mechanisms responsible for development of lymphoproliferative disorders among HCV-positive patients remain unclear. Accumulating evidence supports a model in which chronic stimulation of B-cells by antigens associated with HCV infection causes nonmalignant B-cell expansion that may evolve into B-cell NHL. The course of disease among HCV-positive B-cell NHL patients may be complicated by coinfection with other infectious agents. This possibility has been explored by studies that have investigated potential interactions between HCV and human immunodeficiency virus (HIV) as well as between HCV and Epstein-Barr virus (EBV). Further characterization of the mechanisms by which HCV promotes development of lymphoproliferative disorders may improve diagnosis, classification, and treatment of these conditions.
几种感染因子与淋巴增生性疾病的发生有关。其中包括丙型肝炎病毒（HCV），全球有超过2亿人感染该病毒。HCV感染与II型混合性冷球蛋白血症（MC）综合征的进展有关，也被认为与B细胞非霍奇金淋巴瘤（NHL）的发生有关。HCV阳性患者发生淋巴增生性疾病的机制尚不清楚。越来越多的证据支持一种模型，即与HCV感染相关的抗原对B细胞的慢性刺激会导致非恶性B细胞扩增，进而可能演变为B细胞NHL。HCV阳性B细胞NHL患者的病程可能因合并感染其他感染因子而复杂化。研究已经探讨了这种可能性，这些研究调查了HCV与人类免疫缺陷病毒（HIV）以及HCV与爱泼斯坦-巴尔病毒（EBV）之间的潜在相互作用。进一步阐明HCV促进淋巴增生性疾病发生的机制，可能会改善这些疾病的诊断、分类和治疗。
