Milovanova S Yu, Lysenko Kozlovskaya L V, Milovanova L Yu, Mrykhin N N, Russkih A V, Muchin N A
I.M. Sechenov First Moscow State Medical Univesity, Ministry Health of Russia (Sechenov University), Moscow, Russia.
Clinical Hospital of Moscow Department of Ministry of Internal Affairs of the Russian Federation Health care Unit, Moscow, Russia.
Ter Arkh. 2018 Jun 20;90(6):112-120. doi: 10.26442/terarkh2018906112-120.
Hepatitis C virus (HCV) is a global population problem due to its high prevalence, usually late diagnosis, the difficulties of treatment. In the prognosis of patients with HCV not only hepatic, but increasingly frequent of extrahepatic HCV manifestations, such as mixed cryoglobulinemia (CG), are important. Mixed CG is currently considered as a B-cell benign lymphoproliferative disorders. The role of HCV virus in the pathogenesis of lymphoproliferative diseases is confirmed by a large number of epidemiological studies, as well as by the effectiveness of antiviral therapy in patients with non-Hodgkin's lymphoma (NHL). The purpose of the review was to provide an overview of recent literature data and the meta-analysis of epidemiological data explaining the role of HCV in the development of NHL. The review also discusses the treatment for HCV-associated NHL by antiviral therapy or other therapeutic options, such as chemotherapy.
丙型肝炎病毒（HCV）因其高流行率、通常较晚的诊断以及治疗困难，成为一个全球性的人群问题。在丙型肝炎病毒患者的预后中，不仅肝脏方面，而且肝外丙型肝炎病毒表现（如混合性冷球蛋白血症（CG））越来越频繁出现，这些都很重要。混合性冷球蛋白血症目前被认为是一种B细胞良性淋巴增殖性疾病。大量的流行病学研究以及抗病毒治疗对非霍奇金淋巴瘤（NHL）患者的有效性，证实了丙型肝炎病毒在淋巴增殖性疾病发病机制中的作用。本综述的目的是概述近期的文献数据以及对流行病学数据的荟萃分析，以解释丙型肝炎病毒在非霍奇金淋巴瘤发展中的作用。该综述还讨论了通过抗病毒治疗或其他治疗选择（如化疗）来治疗丙型肝炎病毒相关的非霍奇金淋巴瘤。
