Department of Clinical and Surgical Sciences, Maggiore Hospital, University of Trieste, Trieste, Italy -
Unit of Clinical and Experimental Onco-Hematology, CRO Aviano National Cancer Institute IRCCS, Aviano, Pordenone, Italy.
Minerva Med. 2021 Apr;112(2):215-227. doi: 10.23736/S0026-4806.20.07184-0. Epub 2020 Dec 2.
Hepatitis C virus (HCV) is a global population problem due to its high prevalence worldwide. In the prognosis of patients with HCV not only hepatic but increasingly frequent of extrahepatic HCV manifestations, such as mixed cryoglobulinemia (MC) and non-Hodgkin's lymphoma (NHL), are important. The role of the HCV virus in the pathogenesis of lymphoproliferative diseases is confirmed by a large number of epidemiological studies, as well as by the effectiveness of antiviral therapy in patients with non-Hodgkin's lymphoma (NHL). The purpose of the review was to provide an overview of epidemiological and biological data explaining the role of HCV in the development of NHL. The review also discusses HCV-associated NHL treatment by the traditional antiviral therapy (interferon and ribavirin) and by the new direct antiviral agents.
丙型肝炎病毒 (HCV) 是一个全球性的人口问题，因为它在世界范围内的高患病率。在丙型肝炎患者的预后中，不仅肝脏，而且越来越频繁的肝外丙型肝炎表现，如混合性冷球蛋白血症 (MC) 和非霍奇金淋巴瘤 (NHL)，都很重要。大量的流行病学研究以及抗病毒治疗在非霍奇金淋巴瘤 (NHL) 患者中的有效性证实了 HCV 病毒在淋巴增生性疾病发病机制中的作用。本综述的目的是提供流行病学和生物学数据的概述，解释 HCV 在 NHL 发展中的作用。该综述还讨论了传统抗病毒治疗（干扰素和利巴韦林）和新型直接抗病毒药物治疗 HCV 相关 NHL。
