Pan Zhen-Qiang
Department of Oncological Sciences, Mount Sinai School of Medicine, New York, NY 10029, USA.
Sci STKE. 2005 Jun 21;2005(289):tr18. doi: 10.1126/stke.2892005tr18.
This Teaching Resource provides lecture notes and slides for a class covering the mechanism and regulation of eukaryotic gene transcription machinery and is part of the course "Cell signaling systems: a course for graduate students." This lecture begins with an overview of eukaryotic gene transcription and provides discussions regarding the current models of mechanisms of transcription by RNA polymerase II (Pol II). Recent views on the action of Mediator will also be discussed. Finally, a detailed study will be presented to provide evidence for a role for enhancer-promoter communication in gene activation.
本教学资源提供了涵盖真核基因转录机制与调控的课程讲稿和幻灯片，是“细胞信号系统：研究生课程”的一部分。本次讲座首先对真核基因转录进行概述，并就RNA聚合酶II（Pol II）转录机制的当前模型展开讨论。还将探讨关于中介体作用的最新观点。最后，将进行详细研究，以提供增强子-启动子通讯在基因激活中作用的证据。
