Tausch I, Sönnichsen N
Dermatologische Klinik und Poliklinik, Medizinischen Fakultät (Charité) Humboldt-Universität zu Berlin.
Hautarzt. 1992 Apr;43(4):194-8.
Melkersson-Rosenthal syndrome (MRS) is characterized by the triad of facial paralysis, facial oedema, and lingua plicata in association with other symptoms, such as headache and mental changes. Because the origin of this syndrome is still unknown, only symptomatic treatment is possible. In 18 patients suffering from MRS, whether with a complete or with an incomplete picture, we used the antileprosy drug clofazimine for therapy. A decrease in the frequency and intensity of oedema was achieved by this therapy in 94% of patients. However, improvement persisting throughout a follow-up period of up to 3 years was seen in only 62% of patients. We demonstrate that clofazimine is an alternative to glucocorticosteroids for the treatment of MRS.
梅尔克森 - 罗森塔尔综合征（MRS）的特征为面瘫、面部水肿和皱襞舌三联征，并伴有其他症状，如头痛和精神改变。由于该综合征的病因仍不明，目前仅能进行对症治疗。我们对18例MRS患者（无论症状完整或不完整）使用抗麻风药氯法齐明进行治疗。该治疗使94%的患者水肿频率和严重程度降低。然而，在长达3年的随访期内，只有62%的患者持续改善。我们证明氯法齐明是治疗MRS的糖皮质激素替代药物。
